Coupling of protein relaxation to ligand binding and migration in myoglobin.
نویسنده
چکیده
Protein relaxation, ligand binding, and ligand migration into a hydrophobic cavity in myoglobin are unified by a bounded diffusion model which produces an accurate fit to complex ligand rebinding data over eight decades in time and a 160 K temperature range, in qualitative agreement with time-resolved x-ray crystallography. Protein relaxation operates in a cyclic manner to move the ligand away from the binding site.
منابع مشابه
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عنوان ژورنال:
- Biophysical journal
دوره 87 3 شماره
صفحات -
تاریخ انتشار 2004